Resolution and Repair of Inflammation in Dogs: The Power of Pro-Resolving Mediators
Inflammation is a complex biological response that is crucial for protecting the body from injury and infection. However, when inflammation becomes chronic, it leads to tissue damage and a host of other complications, particularly in aging organisms. Recent research has revealed the importance of Specialized Pro-Resolving Mediators (SPMs) in actively resolving inflammation and repairing tissue damage.
The Body's Natural Defense System: Specialized Pro-Resolving Mediators
Specialized Pro-Resolving Mediators (SPMs) are lipid-derived molecules that play a critical role in terminating inflammation and promoting tissue repair. These include resolvins, protectins, and maresins, which are derived from essential fatty acids like DHA and EPA.
“SPMs don’t just suppress inflammation; they actively resolve it, returning tissues to a state of homeostasis and promoting the healing process.”
In contrast to anti-inflammatory drugs, which merely reduce inflammation, SPMs help clear out inflammatory cells, promote tissue repair, and ensure the immune system returns to normal function.
Source: QUELLED: The Benefits of Specialized Pro-Resolving Factors
How SPMs Work to Resolve Inflammation
SPMs work by signaling the immune system to stop sending inflammatory cells to the site of injury or infection. They help the immune cells clear out dead cells, debris, and harmful pathogens. This process ensures that the inflammation does not continue indefinitely, which would otherwise lead to further tissue damage.
For example, Resolvins are particularly effective in halting the recruitment of neutrophils, the white blood cells that rush to the site of infection or injury and often exacerbate inflammation if not controlled.
Did You Know?
Resolvins, protectins, and maresins are collectively responsible for orchestrating the final phase of the inflammatory response: tissue repair and regeneration. Without them, inflammation would persist, leading to chronic issues such as arthritis, cardiovascular disease, and neurodegenerative disorders.
Benefits of Resolving Inflammation: From Arthritis to Cognitive Function
Resolving inflammation through naturally-occurring pro-resolving mediators has wide-ranging benefits, including:
- Reduced joint pain and improved mobility in cases of arthritis
- Protection against cardiovascular diseases by preventing the buildup of arterial plaques
- Enhanced skin health by reducing inflammatory conditions like dermatitis
- Improved cognitive function by reducing neuroinflammation, a major contributor to Canine Cognitive Dysfunction and Alzheimer’s disease
Chronic Inflammation: A Silent Threat
Many chronic diseases, such as diabetes, cardiovascular disease, and even some cancers, are associated with unresolved chronic inflammation. In dogs, chronic inflammation often manifests as arthritis, itchy skin, or behavioral changes such as anxiety and confusion.
Source: QUELLED: The Benefits of Specialized Pro-Resolving Factors
Ingredients That Support Pro-Resolving Mediators
The eCSeptionOL® Formula, used in products like Quelle365™ Daily Vitality Dog Food Topper, is designed to support the natural production of SPMs. The ingredients, including DHA, PEA, quercetin, and astaxanthin, work synergistically to enhance the body’s ability to resolve inflammation and repair damaged tissues.
Quercetin and DHA: A Powerful Synergy
Quercetin, a flavonoid with anti-inflammatory and antioxidant properties, when combined with DHA, enhances the production of SPMs. This powerful combination has been shown to not only reduce inflammation but also modulate immune response and support tissue repair.
Astaxanthin: The Antioxidant Powerhouse
Astaxanthin, another key ingredient, is known for its potent antioxidant properties. It plays a vital role in supporting joint health and reducing oxidative stress, making it an excellent choice for both aging dogs and humans suffering from chronic inflammation.
Cool Fact:
Astaxanthin, when combined with DHA, not only supports joint health but also significantly improves the body’s response to stress. This synergy enhances the overall efficacy of the eCSeptionOL Formula.
Pro-Resolving Mediators and the Gut-Brain Axis
Recent studies have shown that the gut microbiome plays a crucial role in regulating inflammation throughout the body. A healthy gut environment can help maintain cognitive function and prevent neuroinflammation, a key contributor to Canine Cognitive Dysfunction and Alzheimer’s disease.
Probiotics, such as Lactobacillus acidophilus, support gut health by improving nutrient absorption and enhancing the uptake of key anti-inflammatory ingredients like astaxanthin.
The Gut-Brain Connection
Research has shown that maintaining a healthy gut microbiome can reduce neuroinflammation, improving cognitive function in both dogs and humans. This connection between gut health and brain health underscores the importance of including probiotics in your dog’s diet to promote overall well-being.
Source: QUELLED: The Benefits of Specialized Pro-Resolving Factors
Conclusion: The Power of Pro-Resolving Mediators
As science continues to uncover the mechanisms behind chronic inflammation, it’s clear that resolving inflammation, rather than merely suppressing it, is the key to long-term health and vitality. Specialized Pro-Resolving Mediators, along with supportive ingredients like DHA, PEA, quercetin, and astaxanthin, offer a powerful, natural way to promote healing, prevent chronic diseases, and enhance quality of life for both humans and dogs.
By incorporating products like Quelle365™ into your dog’s daily routine, you can ensure that they benefit from the full spectrum of anti-inflammatory and pro-resolving mediators, helping them live a longer, healthier, and more vibrant life.
Interested in learning more? Visit Quelle365's official page for more information on how to improve your pet’s health through naturally-occurring pro-resolving mediators.
